197. Application can be made to all those things which have been enumerated in the preceding section, as to muscles, nerves, the materials and parts of each kingdom, vegetable and mineral, to the organic substances which are the subjects of thoughts and affections in man, to atmospheres, to heat and light, and to love and wisdom. In all of these, the first is solely regnant in subsequent things, indeed is the only thing in them, and being the only thing in them, is the all in them. That this is the case is clear also from these facts which are well known, namely, that the end is the all of the cause, and that through the cause is the all of the effect, and thus end, cause and effect are called first, middle and last end. Further, it is known that the cause of the cause is also the cause of the thing caused, and that there is nothing essential in causes except the end, and nothing essential in motion except conatus,* also that the substance which is substance in itself is the sole substance. * An urge, effort or striving.